ISO Certificated CAS 1393-88-0 Gramicidin Powder Raw Material Gramicidin Price Health Medical Skin Care Gramicidin

Gramicidin from Bacillus aneurinolyticus (Bacillus brevis) is a linear polypeptide antibiotic with a mixture of gramicidin A, B, C, and D. Gramicidin D is a channel-forming ionophore that flip-flops slowly across the membrane and is a known Pgp substrate and surprisingly was found to inhibit Pgp ATPase activity. This inhibition was reversed by other Pgp substrates suggesting a common drug binding site among MDR substrate-type drugs and chemosensitizers. 
Gramicidin is a lipophilic substance, the two short bacitracin molecules are dimer to the left helix space configuration, constitute a cross-lipid membrane membrane channel to combine and carry a specific cation from the side of the membrane into the channel and then spread to The other side of the membrane, so there is the name of ion antibiotics, so that the cell metabolism can not be normal and inhibited or even death. They have a significant effect on Gram-positive bacteria
The product is white and light yellow crystalline powder. Odorless. Melting point ≥ 229 ºC. Soluble in ethanol, acetic acid, pyridine; slightly soluble in acetone; insoluble in water, ether. Thermal stability, the UV absorption peak of 271,231.5,290.5nm. Not easily digested by protease, but can be acid hydrolysis.